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Nature, Published online: 04 March 2026; doi:10.1038/s41586-026-10155-w

Klenerman and Balasubramanian’s great insight was that template DNA could be sequenced by synthesizing a complementary strand of reversible terminators; basically, extending the chain one base at a time and determining the identity of each nucleotide by looking at the color of its fluorophore. In 1998, the pair started a company called Solexa to develop the technology.

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What might have been, and what might be

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