Scientists created an exam so broad, challenging and deeply rooted in expert human knowledge that current AI systems consistently fail it. “Humanity’s Last Exam” introduces 2,500 questions spanning mathematics, humanities, natural sciences, ancient languages and highly specialized subfields.

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The move came as a surprise to David Juurlink, professor of medicine and pediatrics at the University of Toronto, who has spent over a decade looking into the claim that infants can receive a meaningful or even lethal dose of opioids via breast milk when their mothers take acetaminophen with codeine. The first such case, published in the Lancet in 2006 by pharmacologist Gideon Koren, was the centerpiece of the New Yorker article. (The Lancet case report now bears an expression of concern.) Koren used that case to claim for years that codeine, which gets metabolized to morphine in the body, can pose a lethal risk to breastfeeding infants.

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