Платон Щукин (Редактор отдела «Экономика»)
Cryogenic electron microscopy reveals how dCas12f with σE recruits RNAP to targeted DNA, initiating transcription at a fixed downstream distance, bypassing canonical −35 recognition and stabilizing the −10 element in an unusual manner.
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Farnesyl pyrophosphate—a mevalonate pathway metabolic intermediate—is an endogenous alarmin that enhances IgG antibody responses through keratinocyte-derived IL-6 and CCL20.